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Schiller Lab

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      Chemical Biology                                          BioNanotechnology                                      Synthetic Biology
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Research Schiller Group People Stefan M. Schiller
Presentations Media/Press Lectures

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Stefan M. Schiller
studied chemistry at the Justus Liebig University Gießen, the University of Massachusetts, Amherst and the Johannes Gutenberg University of Mainz.
He received his diploma in organic chemistry in 1998 from the Johannes Gutenberg University. After working on a research project in the main laboratory of the BASF AG, he joined the MPI for Polymer Science where he completed his Ph.D. on biomimetic supramolecular membrane architectures. During this time he performed research at the IBM Research Center Almaden, San Jose, Stanford University, the Biotechnology Engineering Department, Ben Gurion University of the Negev, Beer Sheva, Israel and the Manuel Lujan Los Alamos Neutron Scattering Center, Los Alamos.
Since 2004 he has been a postdoctoral fellow at the Scripps Research Institute, La Jolla, California working on incorporating genetically encoded unnatural amino acids into proteins.
In 2008, he joined the Freiburg Institute for Advanced Studies (FRIAS) at the Albert Ludwigs University in Freiburg, Germany, where he holds a junior research fellow position in the School for Soft Matter Research. His research interests focus on combining macromolecular chemistry with synthetic biology, including genetic engineering of proteins, to access biohybrid materials and to expand the structural & functional toolbox of artificial and natural macromolecules.


Research Focus

    Chemical Biology
Bioorthogonal protein functionalization; heterobisfunctional linker chemistry; lipid and carbohydrate conjugate libraries; novel unnatural amino acids for site specific in vivo translation - introducing defined posttranslational modification pattern; spatiotemporal signaling platforms

    Synthetic Biology & BioNanotechnology
Development of new components for the in vivo translational machinery - tRNA synthetases for the site-specific incorporation of novel unnatural amino acids; novel systems to assemble genetic information to construct nano-defined block copolymer proteins, thermoresponsive protein switches, nano-compartments/artificial organelles in vivo, novel protein-rubbers, scaffolds with adjustable mechanical properties for regenerative medicine; barrel and donut-forming proteins for nanoparticle assembly (e.g. supermagnets), pseudoenzyme moieties; quantum dot based photonic wires and “bio-solar cells”

Polymeric Nanomaterials - nanoparticle controlled enzymatic catalysts e.g. for ring opening polymerization of renewable monomers, green catalysts, oriented nano-confined nano-particle biomineralization and methods of “non-classical” crystallization,  neuro-regeneration via inkjet printing of neuro-interfaces;  programmed 3D scaffolds and asymmetric nano-layer scaffolds for regenerative medicine & stem cell niches


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Revised Jan. 2014 by M. C. Huber