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        Chemical Biology              BioNanotechnology              Synthetic Biology             Nanobiomaterial Science        infilled arrow transp down

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Biohybrid Nanoarchitectures:
Protein Adaptor Based Nano-Object Assembly
(PABNOA)

Functional Expansion of the Cell:
De Novo Organells &
Cellular Modules and Nanoreactors

Biogenic Materials:
Elastine like Proteins
ECM mimicking matrix proteins

Sustainable Biopolymers &
Scaffolds in
Regenerative Medicine

Bioorthogonal Chemistry & Bioconjugation:
Unnatural Amino Acids
Glycolipid Library Tool Box

Modular Molecular Tecton Library
for Biogenic Materials
by One-Vector-Toolbox-Platform (OVTP)

Bioprocess & Enzyme engineering
Peptide Generator
for Biopharmaceuticals

Biomimetic Systems
Membranebiochemistry for
tethered bilayer lipid membranes (tBLM)




       










































A. Bioconjugations via bioorthogonal incorporation of unnatural amino acid (UAA)

 UAA01 UAA03

 UAA02

 UAA05
 UAA06



B. Glycolipid Library Tool Box
 Gycolipid Toolbox

 



Schiller, Stefan M., "Protein Tectons in Synthetic Biology:  The expansion of cellular functionality combining chemical biology of small organic molecules with protein tectons - unnatural amino acids, protein based biohybird materials & de novo organelles", in Synthetic Biology, ed. Giese, B., von Gleich, A., Pade, C., Wigger, H. (Springer, 2014, ISBN 978-3-319-02782-1)

Schreiber, A., Huber, M. C., Coelfen, H., Schiller, S. M. "Protein Adaptor with Genetically Encoded Interaction-Sites Guiding the Hierarchical Assembly of Plasmonically Active Nanoarchitectures"
Nat Commun 6, (2015)


Huber, M. C., Schreiber, A., Wild, W., Benz, K., Schiller, S. M. "Introducing a combinatorial DNA-toolbox platform constituting defined protein-based biohybrid materials"   Biomaterials 2014, 35, 8767-8779

Armen, R. S., Schiller, S. M., Brooks III, C. L. "Steric and Thermodynamic Limits of Design for the Incorporation of Large Un-Natural Amino Acids in Aminoacyl-tRNA Synthetase Enzymes"
Proteins 2010, 78, 1926-1938


Wang, J., Schiller, S. M., *Schultz, P. G. "A Biosynthetic Route to Dehydroalanine-Containing Proteins" Angew. Chem. 2007, 46, 36, 6849-6851

                                                      



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Revised Jan. 2014 by M. C. Huber